"But when he heard that Archelaus was reigning over Judea instead of his father Herod, he was afraid to go there. And being warned by God in a dream, he turned aside into the region of Galilee. And he came and dwelt in a city called Nazareth, that it might be fulfilled which was spoken by the prophets, 'He shall be called a Nazarene'" (Matthew 2:22-23).
Without quoting a specific prophetic reference, Matthew summarized the lowly estate of the Christ by telling of Joseph moving his family to Nazareth (Matt. 2:13-21). The prophets foretold the Messiah would be lowly, despised, and rejected by men (Is. 53:3-6; Zech. 9:9-10).
To be called a "Nazarene" meant more than someone was "from Nazareth." It was a derogatory label of bias drawn from this insignificant town on the northern outskirts of the nation. (Only those of no consequence (like a carpenter) ever came from Nazareth.) Nathaniel expressed the prevailing contempt toward Nazarenes when Philip told him of finding the one of whom Moses and the prophets wrote - Jesus of Nazareth. "Can anything good come out of Nazareth?" was his retort (John 1:45-46).
Prejudice is an ugly thing, and in this case, it led some to reject the Son of God, by using His upbringing in Galilee as proof Jesus was not the Christ (John 7:41-43). Yes, Jesus was "hated without a cause" (John 15:24-25). We must never be driven by prejudice toward anyone, including Jesus. Instead, we should follow the advice Philip gave Nathaniel to "come and see" that Jesus of Nazareth is the Christ (John 1:46).